Ki Summary

Reaction Details

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Target

Adenosine receptor A2b

Ligand

BDBM561414

Substrate/Competitor

n/a

Meas. Tech.

Adenosine A2B Receptor Cyclic AMP GS Assay

EC50

<10±n/a nM

Citation

Huang, T; Wang, X Pyrazolopyridines and triazolopyridines as A2A / A2B inhibitors US Patent US11390624 Publication Date 7/19/2022

More Info.:

Get all data from this article, Assay Method

Adenosine receptor A2b

Name:

Adenosine receptor A2b

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

36341.22

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

332

Sequence:

MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA
IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT
RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT
FHKIISRYLLCQADVKSGNGQAGVQPALGVGL

BDBM561414

n/a

Name

BDBM561414

Synonyms:

3-(4-amino-7-(4-methyloxazol-5-yl)-2-((6-methylpyridin-2-yl)methyl)-2H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)benzonitrile | US11390624, Example 29

Type

Small organic molecule

Emp. Form.

C23H18N8O

Mol. Mass.

422.442

SMILES

Cc1ncoc1-c1c(nc(N)c2nn(Cc3cccc(C)n3)nc12)-c1cccc(c1)C#N |(1.78,2.32,;.32,2.8,;-.16,4.26,;-1.7,4.26,;-2.18,2.8,;-.93,1.9,;-.93,.36,;-2.26,-.41,;-2.26,-1.95,;-.93,-2.72,;-.93,-4.26,;.4,-1.95,;1.87,-2.43,;2.77,-1.18,;4.31,-1.18,;5.08,.15,;4.31,1.48,;5.08,2.82,;6.62,2.82,;7.39,1.48,;8.93,1.48,;6.62,.15,;1.87,.06,;.4,-.41,;-3.6,.36,;-3.6,1.9,;-4.93,2.67,;-6.27,1.9,;-6.27,.36,;-4.93,-.41,;-7.6,-.41,;-8.93,-1.18,)|

Structure