| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] |
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| Ligand | BDBM561449 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TBD |
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| IC50 | 0.052±n/a nM |
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| Citation |  Wu, L; Liu, X; Ding, CZ; Chen, S; Hu, L; Zhao, L; Pan, W; Hu, G; Li, J; Zhao, N; Zhao, J Aryl-phosphorus-oxygen compound as EGFR kinase inhibitor US Patent US11390625 Publication Date 7/19/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] |
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| Name: | Epidermal growth factor receptor [1-18,20-1210,T790M,C797S] |
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| Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR)(del19/T790M/C797S) | HER1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 134190.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[1-18,20-1210,T790M,C797S] |
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| Residue: | 1209 |
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| Sequence: | MRPSGTAGAALLALLAALPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVV
LGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAV
LSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQ
NHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCT
GPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVV
TDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKN
CTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFE
NLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLF
GTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNL
LEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMG
ENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVA
LGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSG
AFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGIC
LTSTVQLIMQLMPFGSLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAAR
NVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYG
VTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKF
RELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQ
GFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDS
IDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNT
VQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVA
PQSSEFIGA
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| BDBM561449 |
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| n/a |
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| Name | BDBM561449 |
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| Synonyms: | US11390625, Compound 23 | US11390625, Example 23 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H38BrN6O2P |
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| Mol. Mass. | 649.561 |
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| SMILES | COc1cc(N2CCC3(CN(C)C3)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc3ccccc3c2P(C)(C)=O)n1 |
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| Structure | 
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