| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase parkin |
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| Ligand | BDBM562070 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Enzyme Activity and Drug Binding |
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| EC50 | 164±n/a nM |
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| Citation |  Springer, W; Fiesel, FC; Caulfield, TR Small molecule activators of Parkin enzyme function US Patent US11401255 Publication Date 8/2/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase parkin |
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| Name: | E3 ubiquitin-protein ligase parkin |
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| Synonyms: | PARK2 | PRKN | PRKN_HUMAN | Parkin | Parkin RBR E3 ubiquitin-protein ligase | Parkinson disease protein 2 | Parkinson juvenile disease protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 51645.70 |
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| Organism: | Human |
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| Description: | O60260 |
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| Residue: | 465 |
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| Sequence: | MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCD
LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA
VILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGP
SCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT
CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE
LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC
GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR
CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV
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| BDBM562070 |
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| n/a |
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| Name | BDBM562070 |
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| Synonyms: | US11401255, Compound # 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18N4O |
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| Mol. Mass. | 354.4045 |
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| SMILES | O=C(Cn1ccnc1-c1ccccn1)Nc1ccc(cc1)-c1ccccc1 |
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| Structure | 
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