| Reaction Details |
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 | Report a problem with these data |
| Target | 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1 |
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| Ligand | BDBM563498 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro pAMPK1 Kinase Activation Assay |
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| EC50 | 0.460±n/a nM |
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| Citation |  Sebhat, I; He, S AMPK activators US Patent US11407768 Publication Date 8/9/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1 |
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| Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1 |
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| Synonyms: | 5'-AMP-activated protein kinase Complex 1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1/beta-1/gamma-1 | AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 | AMPK alpha1/beta1/gamma1 | AMPK complex 1 (alpha-1,beta-1,gamma-1) | Adenosine monophosphate-activated protein kinase (AMPK gamma 1, beta 1 and alpha 1) | Recombinant AMPK alpha1/beta1/gamma1 complex |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 0 components. |
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| Component 1 |
| Name: | 5'-AMP-activated protein kinase subunit beta-1 |
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| Synonyms: | 5'-AMP-activated protein kinase subunit beta-1 | AAKB1_HUMAN | AMP-activated protein kinase alpha-2/beta-1/gamma-3 | AMPK | AMPK subunit beta-1 | AMPKb | PRKAB1 |
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| Type: | n/a |
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| Mol. Mass.: | 30380.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y478 |
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| Residue: | 270 |
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| Sequence: | MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEF
LAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPE
GEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELS
SSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLY
ALSIKDGVMVLSATHRYKKKYVTTLLYKPI
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| Component 2 |
| Name: | 5'-AMP-activated protein kinase subunit gamma-1 |
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| Synonyms: | 5'-AMP-activated protein kinase subunit gamma-1 | AAKG1_HUMAN | AMP-activated protein kinase, gamma-1 subunit | AMPK alpha2/beta2/gamma1 | AMPK gamma-1 | AMPK gamma1 | AMPK subunit gamma-1 | AMPKg | PRKAG1 |
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| Type: | n/a |
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| Mol. Mass.: | 37581.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54619 |
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| Residue: | 331 |
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| Sequence: | METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKA
FFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREV
YLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFI
TEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDI
YSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRL
VVVDENDVVKGIVSLSDILQALVLTGGEKKP
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| Component 3 |
| Name: | 5'-AMP-activated protein kinase catalytic subunit alpha-1 |
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| Synonyms: | AAPK1_HUMAN | ACACA kinase | AMP-activated protein kinase alpha-1/beta-2/gamma-2 | AMP-activated protein kinase, alpha-1 subunit | AMPK subunit alpha-1 | AMPK-alpha1 | AMPK1 | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA1 | Tau-protein kinase PRKAA1 |
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| Type: | Protein |
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| Mol. Mass.: | 64023.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13131 |
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| Residue: | 559 |
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| Sequence: | MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR
QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF
LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG
IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID
DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDI
MAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE
ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG
SHTIEFFEMCANLIKILAQ
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| BDBM563498 |
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| n/a |
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| Name | BDBM563498 |
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| Synonyms: | (2S)-2-amino-3-(4-(2- amino-6-((R)-1-(4- chloro-2-(3-methyl-1H- pyrazole-1-yl)phenyl)- 2,2,2- trifluoroethoxy)pyrimidine- 4-yl)cyclohex-3- ene-1-yl)propionic acid | US11407763, Example 45 | US11407768, Compound 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H29ClN4O8S |
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| Mol. Mass. | 677.123 |
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| SMILES | O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C(=O)NCCc1ccc(cc1)S(O)(=O)=O |r| |
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| Structure | 
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