Reaction Details |
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Target | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
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Ligand | BDBM8718 |
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Substrate/Competitor | Crotonoyl-ACP |
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Meas. Tech. | Enzyme Inhibition Assay |
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Temperature | 303.15±n/a K |
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IC50 | 2600±n/a nM |
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Comments | extracted |
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Citation | Miller, WH; Seefeld, MA; Newlander, KA; Uzinskas, IN; Burgess, WJ; Heerding, DA; Yuan, CC; Head, MS; Payne, DJ; Rittenhouse, SF; Moore, TD; Pearson, SC; Berry, V; DeWolf, WE; Keller, PM; Polizzi, BJ; Qiu, X; Janson, CA; Huffman, WF Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI). J Med Chem45:3246-56 (2002) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
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Name: | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
Synonyms: | Enoyl-ACP Reductase (FabI) | FABI_HAEIN | NADH-dependent enoyl-ACP reductase | envM | fabI |
Type: | Enzyme |
Mol. Mass.: | 28115.25 |
Organism: | Haemophilus influenzae |
Description: | P44432 |
Residue: | 262 |
Sequence: | MGFLTGKRILVTGLASNRSIAYGIAKSMKEQGAELAFTYLNDKLQPRVEEFAKEFGSDIV
LPLDVATDESIQNCFAELSKRWDKFDGFIHAIAFAPGDQLDGDYVNAATREGYRIAHDIS
AYSFVAMAQAARPYLNPNAALLTLSYLGAERAIPNYNVMCLAKASLEAATRVMAADLGKE
GIRVNAISAGPIRTLAASGIKNFKKMLSTFEKTAALRRTVTIEDVGNSAAFLCSDLASGI
TGEIVHVDAGFSITAMGELGEE
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BDBM8718 |
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Crotonoyl-ACP |
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Name: | Crotonoyl-ACP |
Synonyms: | n/a |
Type: | Other Protein Type |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | 1. NAD(P)H is its co-substrate. 2. Crotonoyl-ACP was synthesized using ACP synthase to catalyse the addition of a crotonoyl group from crotonoyl-CoA to apo-ACP |
Residue: | 3 |
Sequence: | |