| Reaction Details |
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 | Report a problem with these data |
| Target | Mast/stem cell growth factor receptor Kit [V560G,D816V] |
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| Ligand | BDBM175679 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Autophosphorylation Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | <10.00±n/a nM |
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| Comments | extracted |
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| Citation |  Hodous, BL Compositions useful for treating disorders related to kit US Patent US9688680 Publication Date 6/27/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mast/stem cell growth factor receptor Kit [V560G,D816V] |
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| Name: | Mast/stem cell growth factor receptor Kit [V560G,D816V] |
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| Synonyms: | KIT | KIT_HUMAN | SCFR | Tyrosine-protein kinase Kit (Kit)(V560G/D816V) |
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| Type: | n/a |
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| Mol. Mass.: | 109812.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human Kit V560G/D816V mutant |
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| Residue: | 976 |
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| Sequence: | MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV
MILTYKYLQKPMYEVQWKVGEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPES
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
GSTASSSQPLLVHDDV
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| BDBM175679 |
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| n/a |
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| Name | BDBM175679 |
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| Synonyms: | US9688680, 224 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H34N6O2 |
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| Mol. Mass. | 486.6086 |
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| SMILES | Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCN(CC2)C(=O)C(C)(C)C)cc1 |t:25| |
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| Structure | 
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