| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM510150 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Human P2X7 Functional Assay |
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| IC50 | <50±n/a nM |
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| Citation |  Arano, Y; Toyoshima, K; Sone, T; Matsubara, K Tetrahydroquinoline derivatives as P2X7 receptor antagonists US Patent US11439633 Publication Date 9/13/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 68602.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99572 |
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| Residue: | 595 |
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| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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| BDBM510150 |
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| n/a |
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| Name | BDBM510150 |
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| Synonyms: | N-(2,4-dichloro-6-(methoxy- methyl)benzyl)-8-hydroxy- 5,6,7,8-tetrahydro- quinoline-5-carboxamide | US11077100, Example 10 | US11439633, Example 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20Cl2N2O3 |
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| Mol. Mass. | 395.28 |
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| SMILES | COCc1cc(Cl)cc(Cl)c1CNC(=O)C1CCC(O)c2ncccc12 |
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| Structure | 
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