| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 9 |
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| Ligand | BDBM307817 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET Kinase Assay |
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| IC50 | 22.0±n/a nM |
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| Citation |  Mastracchio, A; Bruncko, M; Lai, C; Miyashiro, JM; Tao, Z; Woods, KW; Penning, TD; Souers, AJ Pyridine CDK9 kinase inhibitors US Patent US9650358 Publication Date 5/16/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 9 |
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| Name: | Cyclin-dependent kinase 9 |
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| Synonyms: | C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 42789.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 372 |
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| Sequence: | MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP
ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK
FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS
QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL
ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP
ATTNQTEFERVF
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| BDBM307817 |
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| n/a |
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| Name | BDBM307817 |
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| Synonyms: | (3R)-N-{5-chloro-4-[1-(4-fluorobenzyl)-1H-benzotriazol-6-yl]pyridin-2-yl}piperidine-3-carboxamide | US9650358, Example 113 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22ClFN6O |
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| Mol. Mass. | 464.922 |
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| SMILES | Fc1ccc(Cn2nnc3ccc(cc23)-c2cc(NC(=O)[C@@H]3CCCNC3)ncc2Cl)cc1 |
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| Structure | 
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