| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Ligand | BDBM8741 |
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| Substrate/Competitor | BDBM8737 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 6.5±n/a |
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| Temperature | 303.15±n/a K |
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| IC50 | 2030±40 nM |
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| Citation |  Heerding, DA; Chan, G; DeWolf, WE; Fosberry, AP; Janson, CA; Jaworski, DD; McManus, E; Miller, WH; Moore, TD; Payne, DJ; Qiu, X; Rittenhouse, SF; Slater-Radosti, C; Smith, W; Takata, DT; Vaidya, KS; Yuan, CC; Huffman, WF 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI). Bioorg Med Chem Lett11:2061-5 (2001) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Name: | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Synonyms: | Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | FABI_STAAR | NADPH-dependent enoyl-ACP reductase | fabI | trans-2-enoyl-[acyl carrier protein] reductase |
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| Type: | Enzyme |
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| Mol. Mass.: | 27989.00 |
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| Organism: | Staphylococcus aureus |
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| Description: | Q6GI75 |
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| Residue: | 256 |
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| Sequence: | MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA
HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI
SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP
DNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG
VTGENIHVDSGFHAIK
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| BDBM8741 |
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| BDBM8737 |
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| Name | BDBM8741 |
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| Synonyms: | 4-{[4-(thiophen-3-yl)-1H-imidazol-1-yl]methyl}aniline | Disubstituted imidazole 20 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13N3S |
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| Mol. Mass. | 255.338 |
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| SMILES | Nc1ccc(Cn2cnc(c2)-c2ccsc2)cc1 |
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| Structure | 
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