| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminyl-peptide cyclotransferase |
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| Ligand | BDBM308053 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorometric Assay |
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| Ki | 58.8±n/a nM |
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| Citation |  Heiser, U; Ramsbeck, D; Sommer, R; Meyer, A; Hoffmann, T; Boehme, L; Demuth, H Inhibitors US Patent US9650362 Publication Date 5/16/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminyl-peptide cyclotransferase |
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| Name: | Glutaminyl-peptide cyclotransferase |
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| Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 40877.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16769 |
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| Residue: | 361 |
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| Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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| BDBM308053 |
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| n/a |
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| Name | BDBM308053 |
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| Synonyms: | (S)-2-(1H-benzo[d]imidazol- 5-yl)-3-(4- propoxyphenyl)isoindolin- 1-one | US9650362, 145 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21N3O2 |
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| Mol. Mass. | 383.4424 |
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| SMILES | CCCOc1ccc(cc1)[C@@H]1N(C(=O)c2ccccc12)c1ccc2[nH]cnc2c1 |r| |
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| Structure | 
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