| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-A2/Cyclin-dependent kinase 2 |
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| Ligand | BDBM572063 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Protein Kinase Assay Condition B (Thiol-Free Conditions) |
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| IC50 | 5500±n/a nM |
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| Citation |  Kanouni, T; Arnold, L; Kaldor, SW; Murphy, EA Inhibitors of cyclin-dependent kinases US Patent US11447493 Publication Date 9/20/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-A2/Cyclin-dependent kinase 2 |
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| Name: | Cyclin-A2/Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2/Cyclin A |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1655488 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| Component 2 |
| Name: | Cyclin-A2 |
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| Synonyms: | CCNA2 | CCNA2_BOVIN | Cyclin-A | Cyclin-A2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48258.58 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_117723 |
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| Residue: | 430 |
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| Sequence: | MLGSSAHGPAAREAGSAVTLQQTAFQEDQENVNPEKAAPAQQPRTRAGLAVLRAGNSRGP
APQRPKTRRVAPLKDLPINDEYVPVPPWKANNKQPAFTIHVDEAEEEIQKRPTESKKSES
EDVLAFNSAVTLPGPRKPLAPLDYPMDGSFESPHTMEMSVVLEDEKPVSVNEVPDYHEDI
HTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRF
LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVL
AFDLAAPTINQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAAAAFHL
ALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIREKYKNSKYHGVS
LLNPPETLNV
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| BDBM572063 |
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| n/a |
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| Name | BDBM572063 |
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| Synonyms: | (R)-N-(4-(3-((6-fluoroquinazolin-2- yl)amino)pyrrolidine-1- carbonyl)phenyl)acrylamide | US11447493, Example 28 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20FN5O2 |
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| Mol. Mass. | 405.4249 |
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| SMILES | Fc1ccc2nc(N[C@@H]3CCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)ncc2c1 |r| |
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| Structure | 
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