Reaction Details |
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Target | Caspase-9 |
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Ligand | BDBM572147 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition of Caspase Activity Assay |
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IC50 | 107±n/a nM |
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Citation | Spada, AP; Ternansky, RJ (S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases US Patent US11447497 Publication Date 9/20/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Caspase-9 |
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Name: | Caspase-9 |
Synonyms: | Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein |
Type: | Enzyme |
Mol. Mass.: | 46277.29 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 416 |
Sequence: | MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
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BDBM572147 |
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n/a |
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Name | BDBM572147 |
Synonyms: | US11447497, Example 4 |
Type | Small organic molecule |
Emp. Form. | C23H23F4N3O7S |
Mol. Mass. | 561.503 |
SMILES | OC(=O)C[C@H](NC(=O)CN1CCN(CC1)S(=O)(=O)c1ccccc1)C(=O)COc1c(F)c(F)cc(F)c1F |r,$;;;;;HN;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$| |
Structure |
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