| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase LATS1 |
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| Ligand | BDBM573863 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LATS1 Biochemical Assay: Homogenous Time Resolved Fluorescence (HTRF) Assay |
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| IC50 | 1.000±n/a nM |
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| Citation |  Behnke, D; Berenshteyn, F; Hao, X; Hoffman, T; Jin, Q; Lacoste, A; Lee, C; Liu, J; Liu, Y; Maibaum, JK; Mo, T; Pan, J; Qu, X; Tchorz, J; Xie, YF; Yan, S; Zou, Y 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors US Patent US11458138 Publication Date 10/4/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase LATS1 |
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| Name: | Serine/threonine-protein kinase LATS1 |
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| Synonyms: | LATS1 | LATS1_HUMAN | WARTS |
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| Type: | PROTEIN |
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| Mol. Mass.: | 126893.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774443 |
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| Residue: | 1130 |
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| Sequence: | MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTE
DPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVI
QALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKG
SKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPP
QVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGY
PPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQ
NVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNME
LYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQ
PSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNV
TVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENV
DSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHR
KKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVC
LARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYF
VMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDG
HIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAAR
QHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQM
KVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLR
QQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTF
RRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV
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| BDBM573863 |
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| n/a |
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| Name | BDBM573863 |
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| Synonyms: | US11458138, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17N5 |
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| Mol. Mass. | 279.3397 |
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| SMILES | CCN(CC)c1nc(nc2cnccc12)-c1ccncc1 |
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| Structure | 
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