| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase LATS2 |
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| Ligand | BDBM574408 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LATS2 Biochemical Caliper Assay |
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| IC50 | 34.0±n/a nM |
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| Citation |  Behnke, D; Berenshteyn, F; Hao, X; Hoffman, T; Jin, Q; Lacoste, A; Lee, C; Liu, J; Liu, Y; Maibaum, JK; Mo, T; Pan, J; Qu, X; Tchorz, J; Xie, YF; Yan, S; Zou, Y 6-6 fused bicyclic heteroaryl compounds and their use as LATS inhibitors US Patent US11458138 Publication Date 10/4/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase LATS2 |
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| Name: | Serine/threonine-protein kinase LATS2 |
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| Synonyms: | KPM | LATS2 | LATS2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 120160.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_587187 |
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| Residue: | 1088 |
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| Sequence: | MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQ
QQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRA
LKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSF
ASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVE
AAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGA
GLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLY
ELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPG
KAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPA
AEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGM
EQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPY
AFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKR
AKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDIL
AEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIE
SVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSD
LWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVG
VILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLG
RNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTK
AWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQT
EGCQPVYV
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| BDBM574408 |
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| n/a |
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| Name | BDBM574408 |
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| Synonyms: | US11458138, Example 288 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13F3N4 |
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| Mol. Mass. | 330.3071 |
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| SMILES | FC(F)(F)C1(CC1)Nc1nc(cc2cnccc12)-c1ccncc1 |
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| Structure | 
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