| Reaction Details |
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 | Report a problem with these data |
| Target | Envelope glycoprotein |
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| Ligand | BDBM574754 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of Authentic Filovirus Infections in Cell Culture Assays |
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| IC50 | 730±n/a nM |
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| Citation |  Bowlin, TL; Moir, DT; Chandran, K; Dye, Jr., JM; Williams, JD; Aron, ZD; Barbor, JP; Lively, KN; Nash, PJ; Mills, DM; Basu, A Broad spectrum inhibitors of filoviruses US Patent US11459308 Publication Date 10/4/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Envelope glycoprotein |
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| Name: | Envelope glycoprotein |
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| Synonyms: | GP | GP1,2 | VGP_EBOZ5 |
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| Type: | Protein |
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| Mol. Mass.: | 74450.60 |
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| Organism: | ZEBOV |
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| Description: | P87666 |
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| Residue: | 676 |
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| Sequence: | MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVSDVDKLVCRDKLSST
NQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSE
CLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGV
VAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLT
YVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRK
IRSEELSFTAVSNRAKNISGQSPARTSSDPGTNTTTEDHKIMASENSSAMVQVHSQGREA
AVSHLTTLATISTSPQPPTTKPGPDNSTHNTPVYKLDISEATQVEQHHRRTDNDSTASDT
PPATTAAGPLKAENTNTSKGTDLLDPATTTSPQNHSETAGNNNTHHQDTGEESASSGKLG
LITNTIAGVAGLITGGRRARREAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAE
GIYTEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGT
CHILGPDCCIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTG
VIIAVIALFCICKFVF
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| BDBM574754 |
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| n/a |
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| Name | BDBM574754 |
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| Synonyms: | US11459308, Compound 3588 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30N4O2 |
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| Mol. Mass. | 442.5527 |
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| SMILES | [O-][N+](=O)c1ccc(cc1NC(c1ccccc1)c1ccccc1)N1CCN(CC1)C1CCC1 |
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| Structure | 
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