| Reaction Details |
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 | Report a problem with these data |
| Target | Activin receptor type-1 [147-509] |
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| Ligand | BDBM575188 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ALK2 HTRF Assay |
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| IC50 | <1±n/a nM |
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| Citation |  Pan, J; Roach, J; Mei, S; He, C; Wu, L; Yao, W Imidazopyridazine and imidazopyridine compounds and uses thereof US Patent US11459329 Publication Date 10/4/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Activin receptor type-1 [147-509] |
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| Name: | Activin receptor type-1 [147-509] |
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| Synonyms: | ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor-like kinase 2 (ALK-2) (aa 147-509) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 41331.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa147-end |
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| Residue: | 363 |
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| Sequence: | RKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVAR
QITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFI
ASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGT
QGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEV
LDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRK
VVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLK
TDC
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| BDBM575188 |
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| n/a |
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| Name | BDBM575188 |
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| Synonyms: | US11459329, Example 62 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24N10O |
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| Mol. Mass. | 492.5352 |
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| SMILES | Cc1cnn(n1)-c1ccc2c(ccnc2n1)-c1cnc2cc(-c3cnn(c3)C3CCOCC3)c(C)nn12 |
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| Structure | 
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