Reaction Details |
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Target | Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 |
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Ligand | BDBM576884 |
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Substrate/Competitor | n/a |
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Meas. Tech. | CDK2/Cyclin E1 HERE Enzyme Activity Assay |
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IC50 | <50±n/a nM |
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Citation | Hummel, J; Li, J; Li, Z; Qian, D; Wu, L; Xiao, K; Xu, M; Yang, JC; Yao, W; Zhang, F; Ye, M; Chen, Y; Favata, M; Lo, Y Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors US Patent US11472791 Publication Date 10/18/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 |
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Name: | Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 |
Synonyms: | CDK2/CycE | CDK2/Cyclin E | CDK2/E | CDK2/E1 | Cyclin-Dependent Kinase 2 (CDK2) | Cyclin-dependent kinase 2/G1/S-specific cyclin E1 | Cyclin-dependent kinase 2/cyclin E1 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cyclin-dependent kinase 2 |
Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 33938.17 |
Organism: | Homo sapiens (Human) |
Description: | P24941 |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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Component 2 |
Name: | G1/S-specific cyclin-E1 |
Synonyms: | CCNE | CCNE1 | CCNE1_HUMAN |
Type: | Enzyme Subunit |
Mol. Mass.: | 47073.17 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 410 |
Sequence: | MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQ
PWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIM
LNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQ
ENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR
LSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILA
ASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNI
QTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
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BDBM576884 |
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n/a |
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Name | BDBM576884 |
Synonyms: | 1-(4-(2-(((3R,4S)-3- Fluoro-1-((3-((R)-3- methoxypyrrolidin-1- yl)propyl)sulfonyl)piperidin- 4-yl)amino)-5- (trifluoromethyl)pyrimidin- 4-yl)-1H-pyrazol-1-yl)- 2-methylpropan-2-ol | US11472791, Example 206 |
Type | Small organic molecule |
Emp. Form. | C25H37F4N7O4S |
Mol. Mass. | 607.664 |
SMILES | CO[C@@H]1CCN(CCCS(=O)(=O)N2CC[C@H](Nc3ncc(c(n3)-c3cnn(CC(C)(C)O)c3)C(F)(F)F)[C@H](F)C2)C1 |r| |
Structure |
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