| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825] |
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| Ligand | BDBM577126 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Scintillation Proximity Assay |
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| IC50 | <0.450±n/a nM |
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| Citation |  Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Chandrasekaran, RY Tricyclic compounds and their use as phosphodiesterase inhibitors US Patent US11472805 Publication Date 10/18/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825] |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825] |
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| Synonyms: | DPDE2 | PDE4A | PDE4A_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase (PDE4A3) (2-825) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 92170.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 2-825 |
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| Residue: | 824 |
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| Sequence: | EPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQP
HRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRS
PLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPF
AQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWC
LEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIP
SPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQ
EELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT
LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS
NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV
LATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLEL
YRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLV
HPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEI
SMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQ
QAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWR
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| BDBM577126 |
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| n/a |
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| Name | BDBM577126 |
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| Synonyms: | 10-(4-Chloro-3-fluorophenyl)-8-cyclopropyl-7,8-dihydropyrido[2',3':4,5]pyrrolo[1,2-a]pyrazin-9(6H)-one | US11472805, Example 32 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15ClFN3O |
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| Mol. Mass. | 355.793 |
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| SMILES | Fc1cc(ccc1Cl)-c1c2C(=O)N(CCn2c2cccnc12)C1CC1 |
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| Structure | 
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