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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736] | ||
| Ligand | BDBM577162 | ||
| Substrate/Competitor | n/a | ||
| IC50 | 6.87±n/a nM | ||
| Citation |  Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Chandrasekaran, RY Tricyclic compounds and their use as phosphodiesterase inhibitors US Patent US11472805 Publication Date 10/18/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736] | |||
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736] | ||
| Synonyms: | DPDE4 | PDE4B | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B1 (PDE4B)(122-736) | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 70260.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | aa 122 to 736 | ||
| Residue: | 615 | ||
| Sequence: |
| ||
| BDBM577162 | |||
| n/a | |||
| Name | BDBM577162 | ||
| Synonyms: | 8-Cyclopropyl-10-(2,4-dimethyl-phenyl)pyrido[2',3':4,5]pyrrolo[1,2-a]pyrazin-9(8H)-one | US11472805, Example 66 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H19N3O | ||
| Mol. Mass. | 329.3951 | ||
| SMILES | Cc1ccc(-c2c3ncccc3n3ccn(C4CC4)c(=O)c23)c(C)c1 |(.96,4.96,;.48,3.49,;1.51,2.35,;1.04,.89,;-.47,.57,;-.94,-.9,;-2.41,-1.38,;-3.74,-.61,;-5.08,-1.38,;-5.08,-2.92,;-3.74,-3.69,;-2.41,-2.92,;-.94,-3.39,;-.32,-4.8,;1.21,-4.96,;2.12,-3.71,;3.65,-3.87,;4.87,-4.82,;5.08,-3.29,;1.49,-2.31,;2.4,-1.06,;-.04,-2.15,;-1.5,1.71,;-3,1.39,;-1.02,3.17,)| | ||
| Structure | 
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