| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736] |
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| Ligand | BDBM577163 |
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| Substrate/Competitor | n/a |
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| IC50 | 4.93±n/a nM |
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| Citation |  Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Chandrasekaran, RY Tricyclic compounds and their use as phosphodiesterase inhibitors US Patent US11472805 Publication Date 10/18/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736] |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736] |
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| Synonyms: | DPDE4 | PDE4B | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B1 (PDE4B)(122-736) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 70260.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 122 to 736 |
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| Residue: | 615 |
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| Sequence: | ATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRN
NFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRS
VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKK
QQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHN
RPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVL
LSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLA
VGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSS
GVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEIS
PMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPS
PPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGE
TDIDIATEDKSPVDT
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| BDBM577163 |
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| n/a |
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| Name | BDBM577163 |
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| Synonyms: | 11-(4-Chlorophenyl)-6,6a,7,8-tetrahydro-10H-azeto[1,2-a]pyrido[2',3':4,5]pyrrolo[1,2-d]pyrazin-10-one | US11472805, Example 67 | US11472805, Example 68 | US11472805, Example 69 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14ClN3O |
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| Mol. Mass. | 323.776 |
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| SMILES | Clc1ccc(cc1)-c1c2C(=O)N3CCC3Cn2c2cccnc12 |
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| Structure | 
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