| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825] |
|---|
| Ligand | BDBM577163 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Scintillation Proximity Assay |
|---|
| IC50 | 8.87±n/a nM |
|---|
| Citation |  Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Chandrasekaran, RY Tricyclic compounds and their use as phosphodiesterase inhibitors US Patent US11472805 Publication Date 10/18/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825] |
|---|
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825] |
|---|
| Synonyms: | DPDE2 | PDE4A | PDE4A_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase (PDE4A3) (2-825) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 92170.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | aa 2-825 |
|---|
| Residue: | 824 |
|---|
| Sequence: | EPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQP
HRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRS
PLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPF
AQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWC
LEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIP
SPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQ
EELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT
LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS
NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV
LATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLEL
YRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLV
HPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEI
SMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQ
QAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWR
|
|
|
|---|
| BDBM577163 |
|---|
| n/a |
|---|
| Name | BDBM577163 |
|---|
| Synonyms: | 11-(4-Chlorophenyl)-6,6a,7,8-tetrahydro-10H-azeto[1,2-a]pyrido[2',3':4,5]pyrrolo[1,2-d]pyrazin-10-one | US11472805, Example 67 | US11472805, Example 68 | US11472805, Example 69 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H14ClN3O |
|---|
| Mol. Mass. | 323.776 |
|---|
| SMILES | Clc1ccc(cc1)-c1c2C(=O)N3CCC3Cn2c2cccnc12 |
|---|
| Structure | 
|
|---|
Search and Browse
