Reaction Details |
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825] |
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Ligand | BDBM577182 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Scintillation Proximity Assay |
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IC50 | 2.52±n/a nM |
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Citation | Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Chandrasekaran, RY Tricyclic compounds and their use as phosphodiesterase inhibitors US Patent US11472805 Publication Date 10/18/2022 |
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More Info.: | Get all data from this article, Assay Method |
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cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825] |
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Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825] |
Synonyms: | DPDE2 | PDE4A | PDE4A_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase (PDE4A3) (2-825) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 92170.87 |
Organism: | Homo sapiens (Human) |
Description: | aa 2-825 |
Residue: | 824 |
Sequence: | EPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQP
HRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRS
PLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPF
AQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWC
LEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIP
SPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQ
EELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLT
LEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVS
NQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMV
LATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLEL
YRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLV
HPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEI
SMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQ
QAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWR
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BDBM577182 |
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n/a |
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Name | BDBM577182 |
Synonyms: | 10-Cyclopentyl-8-cyclopropyl-7,8-dihydropyrido[2',3':4,5]pyrrolo[1,2-a]pyrazin-9(6H)-one | US11472805, Example 86 |
Type | Small organic molecule |
Emp. Form. | C18H21N3O |
Mol. Mass. | 295.3788 |
SMILES | O=C1N(CCn2c1c(C1CCCC1)c1ncccc21)C1CC1 |
Structure |
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