| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine deaminase |
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| Ligand | BDBM577224 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Luciferase Reporter Assay |
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| IC50 | 1.40±n/a nM |
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| Citation |  Zhang, G; Zhou, C Pyrazolotriazolopyrimidine derivatives as A2A receptor antagonist US Patent US11472811 Publication Date 10/18/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine deaminase |
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| Name: | Adenosine deaminase |
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| Synonyms: | ADA | ADA1 | ADA_HUMAN | Adenosine aminohydrolase |
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| Type: | Enzyme |
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| Mol. Mass.: | 40759.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant ADA was expressed and purified from an ADA-deficient bacterial strain. |
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| Residue: | 363 |
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| Sequence: | MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL
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| BDBM577224 |
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| n/a |
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| Name | BDBM577224 |
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| Synonyms: | 2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-phenyl-N-(3-(trifluoromethyl)benzyl)acetamide | US11472811, Example 22 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H19F3N8O2 |
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| Mol. Mass. | 532.4767 |
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| SMILES | Nc1nc2n(ncc2c2nc(nn12)-c1ccco1)C(C(=O)NCc1cccc(c1)C(F)(F)F)c1ccccc1 |
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| Structure | 
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