| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 2 |
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| Ligand | BDBM13066 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme (COXs) Inhibition Assay |
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| IC50 | 20.0±1 nM |
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| Citation |  Elsayed, MK; Burayk, S Method for treating inflammation US Patent US11478464 Publication Date 10/25/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 2 |
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| Name: | Prostaglandin G/H synthase 2 |
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| Synonyms: | COX2 | Cyclooxygenase-2 (COX-2) | PGH2_HUMAN | PTGS2 | Prostaglandin endoperoxide H synthase-2 (PGHS-2)(FLAG-Native) |
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| Type: | Enzyme |
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| Mol. Mass.: | 69995.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35354; containing a FLAG tag at the N terminus |
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| Residue: | 612 |
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| Sequence: | DYKDDDDKMLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGE
NCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDS
PPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRK
FIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRL
FKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWL
REHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELL
FNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESF
TRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKE
MSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWK
PSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDIN
PTVLLKERSTEL
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| BDBM13066 |
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| n/a |
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| Name | BDBM13066 |
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| Synonyms: | 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid | CHEMBL139 | Diclofenac | US11337935, Compound Diclofenac | US11478464, Compound Diclofenac | US11786535, Compound Diclofenac | {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11Cl2NO2 |
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| Mol. Mass. | 296.149 |
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| SMILES | OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl |
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| Structure | 
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