| Reaction Details |
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 | Report a problem with these data |
| Target | Rho-associated protein kinase 2 [1-552] |
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| Ligand | BDBM578479 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Z-lyte assay |
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| IC50 | 1.60±n/a nM |
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| Citation |  Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R; Zhang, J Inhibitors of Rho associated coiled-coil containing protein kinase US Patent US11479533 Publication Date 10/25/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| Rho-associated protein kinase 2 [1-552] |
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| Name: | Rho-associated protein kinase 2 [1-552] |
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| Synonyms: | KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 63353.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 1-552 |
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| Residue: | 552 |
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| Sequence: | MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP
ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM
KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD
ETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLV
GTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENL
LLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKT
AKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
EDLKKRNQNSQI
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| BDBM578479 |
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| n/a |
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| Name | BDBM578479 |
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| Synonyms: | (S)—N-(2-(2-(dimethylamino)ethoxy)-5-fluoro-4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-2-(methylamino)acetamide | US11479533, Example 73 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28FN5O3 |
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| Mol. Mass. | 441.4985 |
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| SMILES | CN[C@H](C(=O)Nc1cc(F)c(cc1OCCN(C)C)-c1cn[nH]c1)c1cccc(OC)c1 |r| |
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| Structure | 
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