| Reaction Details |
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 | Report a problem with these data |
| Target | 2-acylglycerol O-acyltransferase 2 |
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| Ligand | BDBM211296 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MGAT LCMS Assay |
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| IC50 | 9.00±n/a nM |
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| Citation |  Ahmad, S Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors US Patent US11479538 Publication Date 10/25/2022 |
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| More Info.: | Get all data from this article, Assay Method |
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| 2-acylglycerol O-acyltransferase 2 |
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| Name: | 2-acylglycerol O-acyltransferase 2 |
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| Synonyms: | 2-acylglycerol O-acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 | Acyl-CoA:monoacylglycerol acyltransferase 2 (MOGAT2) | DC5 | DGAT2L5 | Diacylglycerol O-acyltransferase candidate 5 | Diacylglycerol acyltransferase 2-like protein 5 | MGAT2 | MOGAT2 | MOGT2_HUMAN | Monoacylglycerol Acyltransferase 2 (MGAT2) | Monoacylglycerol O-acyltransferase 2 | hDC5 | hMGAT2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 38210.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q3SYC2 |
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| Residue: | 334 |
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| Sequence: | MVEFAPLFMPWERRLQTLAVLQFVFSFLALAEICTVGFIALLFTRFWLLTVLYAAWWYLD
RDKPRQGGRHIQAIRCWTIWKYMKDYFPISLVKTAELDPSRNYIAGFHPHGVLAVGAFAN
LCTESTGFSSIFPGIRPHLMMLTLWFRAPFFRDYIMSAGLVTSEKESAAHILNRKGGGNL
LGIIVGGAQEALDARPGSFTLLLRNRKGFVRLALTHGAPLVPIFSFGENDLFDQIPNSSG
SWLRYIQNRLQKIMGISLPLFHGRGVFQYSFGLIPYRRPITTVVGKPIEVQKTLHPSEEE
VNQLHQRYIKELCNLFEAHKLKFNIPADQHLEFC
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| BDBM211296 |
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| n/a |
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| Name | BDBM211296 |
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| Synonyms: | US10093650, Example 11 | US10329273, Example 11 | US11479538, Example 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24F7N7O2 |
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| Mol. Mass. | 587.4926 |
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| SMILES | Fc1cc(CCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(CC3CC3)n2)=C(C(=O)N1)n1nn[nH]c1=O)C(F)(F)F |r,c:29| |
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| Structure | 
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