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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial | ||
| Ligand | BDBM50549954 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | In Vitro Assay: DHODH Enzymatic Assay | ||
| IC50 | 0.222±n/a nM | ||
| Citation |  Kuduk, S; Zhang, Z; DeRatt, L; Wang, A Dihydroorotate dehydrogenase inhibitors US Patent US11505536 Publication Date 11/22/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dihydroorotate dehydrogenase (quinone), mitochondrial | |||
| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial | ||
| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 42881.33 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q02127 | ||
| Residue: | 395 | ||
| Sequence: |
| ||
| BDBM50549954 | |||
| n/a | |||
| Name | BDBM50549954 | ||
| Synonyms: | CHEMBL4791380 | US11505536, Example 11 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H21ClF2N4O3 | ||
| Mol. Mass. | 474.888 | ||
| SMILES | CCn1c(CO)nn(-c2cc3c(cn(-c4c(F)cccc4Cl)c(=O)c3cc2F)C(C)C)c1=O |(16.55,-8.54,;15.93,-7.13,;14.4,-6.97,;13.63,-5.64,;14.25,-4.23,;15.78,-4.07,;12.12,-5.96,;11.96,-7.49,;10.63,-8.25,;9.3,-7.49,;7.97,-8.25,;6.63,-7.48,;5.29,-8.25,;5.3,-9.79,;3.97,-10.56,;3.97,-12.11,;5.31,-12.88,;2.64,-12.88,;1.3,-12.11,;1.3,-10.57,;2.63,-9.8,;2.63,-8.26,;6.64,-10.56,;6.64,-12.1,;7.96,-9.8,;9.29,-10.57,;10.63,-9.8,;11.96,-10.58,;6.63,-5.94,;7.96,-5.17,;5.3,-5.17,;13.37,-8.11,;13.69,-9.62,)| | ||
| Structure | 
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