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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial | ||
| Ligand | BDBM50549951 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | In Vitro Assay: DHODH Enzymatic Assay | ||
| IC50 | 0.265±n/a nM | ||
| Citation |  Kuduk, S; Zhang, Z; DeRatt, L; Wang, A Dihydroorotate dehydrogenase inhibitors US Patent US11505536 Publication Date 11/22/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dihydroorotate dehydrogenase (quinone), mitochondrial | |||
| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial | ||
| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 42881.33 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q02127 | ||
| Residue: | 395 | ||
| Sequence: |
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| BDBM50549951 | |||
| n/a | |||
| Name | BDBM50549951 | ||
| Synonyms: | CHEMBL4745588 | US11505536, Example 52 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H19ClF2N4O3 | ||
| Mol. Mass. | 472.872 | ||
| SMILES | CCn1c(CO)nn(-c2cc3c(cn(-c4c(F)cccc4Cl)c(=O)c3cc2F)C(C)=C)c1=O |(36.41,-17.81,;35.78,-16.4,;34.25,-16.24,;33.48,-14.91,;34.11,-13.5,;35.64,-13.34,;31.98,-15.23,;31.82,-16.76,;30.49,-17.53,;29.15,-16.76,;27.82,-17.52,;26.49,-16.75,;25.15,-17.53,;25.16,-19.06,;23.82,-19.83,;22.49,-19.07,;22.48,-17.53,;21.16,-19.84,;21.16,-21.39,;22.49,-22.16,;23.83,-21.38,;25.16,-22.15,;26.49,-19.83,;26.5,-21.37,;27.82,-19.07,;29.15,-19.84,;30.49,-19.08,;31.82,-19.85,;26.49,-15.21,;27.82,-14.44,;25.15,-14.44,;33.22,-17.39,;33.54,-18.89,)| | ||
| Structure | 
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