| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysine-specific histone demethylase 1A |
|---|
| Ligand | BDBM456485 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibitory Activity (In Vitro) |
|---|
| IC50 | 0.140±n/a nM |
|---|
| Citation |  Osada, A Anti-tumor effect potentiator using novel biphenyl compound US Patent US11510915 Publication Date 11/29/2022 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysine-specific histone demethylase 1A |
|---|
| Name: | Lysine-specific histone demethylase 1A |
|---|
| Synonyms: | AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 92901.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60341 |
|---|
| Residue: | 852 |
|---|
| Sequence: | MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTP
RKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEY
REMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQ
SRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSF
GMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKC
PLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQE
KHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFAN
ATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGC
EVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLN
KVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPI
TPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQA
TPGVPAQQSPSM
|
|
|
|---|
| BDBM456485 |
|---|
| n/a |
|---|
| Name | BDBM456485 |
|---|
| Synonyms: | US10723742, Example 211 | US11510915, Example 211 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H29ClF2N6O2 |
|---|
| Mol. Mass. | 591.051 |
|---|
| SMILES | CC(C)(O)Cn1nnc2cc(c(F)c(Cl)c12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1C2CCC1CC(N)C2 |THB:40:39:35.36:33| |
|---|
| Structure | 
|
|---|
Search and Browse
