Reaction Details |
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Target | Cytochrome P450 11B2, mitochondrial |
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Ligand | BDBM8871 |
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Substrate/Competitor | BDBM8582 |
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Meas. Tech. | CYP11B Assay |
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IC50 | 9.6±n/a nM |
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Citation | Ulmschneider, S; Muller-Vieira, U; Mitrenga, M; Hartmann, RW; Oberwinkler-Marchais, S; Klein, CD; Bureik, M; Bernhardt, R; Antes, I; Lengauer, T Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. J Med Chem48:1796-805 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Cytochrome P450 11B2, mitochondrial |
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Name: | Cytochrome P450 11B2, mitochondrial |
Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
Type: | Protein |
Mol. Mass.: | 57582.15 |
Organism: | Homo sapiens (Human) |
Description: | P19099 |
Residue: | 503 |
Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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BDBM8871 |
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BDBM8582 |
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Name | BDBM8871 |
Synonyms: | 5-[(1E)-1,2,3,4-tetrahydronaphthalen-1-ylidenemethyl]-1H-imidazole | 5-[(E)-3,4-Dihydronaphthalen-1(2H)-ylidenemethyl]-1H-imidazole | Imidazolylmethylenetetrahydronaphthalene 1a | Imidazolylmethylenetetrahydronaphthalene 1b |
Type | Small organic molecule |
Emp. Form. | C14H14N2 |
Mol. Mass. | 210.2744 |
SMILES | C1CC(=Cc2cnc[nH]2)c2ccccc2C1 |w:3.3| |
Structure |
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