Reaction Details |
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Target | Bifunctional dihydrofolate reductase-thymidylate synthase |
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Ligand | BDBM585318 |
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Substrate/Competitor | n/a |
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Meas. Tech. | TBD |
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IC50 | 7.94±n/a nM |
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Citation | Thomas, SB; Hopper, AT; Welsch, M Compositions and methods for treating infections US Patent US11530198 Publication Date 12/20/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Bifunctional dihydrofolate reductase-thymidylate synthase |
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Name: | Bifunctional dihydrofolate reductase-thymidylate synthase |
Synonyms: | DHFR-TS | DRTS_LEIMA | Thymidylate synthase (TS) |
Type: | Protein |
Mol. Mass.: | 58691.04 |
Organism: | Leishmania major |
Description: | P07382 |
Residue: | 520 |
Sequence: | MSRAAARFKIPMPETKADFAFPSLRAFSIVVALDMQHGIGDGESIPWRVPEDMTFFKNQT
TLLRNKKPPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGQR
AAAAQDVVVVNGGLAEALRLLARPLYCSSIETAYCVGGAQVYADAMLSPCIEKLQEVYLT
RIYATAPACTRFFPFPPENAATAWDLASSQGRRKSEAEGLEFEICKYVPRNHEERQYLEL
IDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGE
TSAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDG
EGVDQIKLIVETIKTNPNDRRLLVTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLY
QRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVDALKAQLERVP
HAFPTLIFKEERQYLEDYELTDMEVIDYVPHPAIKMEMAV
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BDBM585318 |
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n/a |
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Name | BDBM585318 |
Synonyms: | 5-(4-(3-(tetrahydro-2H-pyran-4- yl)phenyl)piperazin-1- yl)pyrimidine-2,4-diamine | US11530198, Example 110 |
Type | Small organic molecule |
Emp. Form. | C19H26N6O |
Mol. Mass. | 354.4493 |
SMILES | Nc1ncc(N2CCN(CC2)c2cccc(c2)C2CCOCC2)c(N)n1 |
Structure |
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