| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit alpha type-6 |
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| Ligand | BDBM50069989 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Proteasome Inhibitory Activity |
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| IC50 | 9.92±n/a nM |
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| Citation |  Qin, Y Synthesis of peptide borate ester compound and use thereof US Patent US11542283 Publication Date 1/3/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Proteasome subunit alpha type-6 |
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| Name: | Proteasome subunit alpha type-6 |
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| Synonyms: | 27 kDa prosomal protein | Macropain iota chain | Multicatalytic endopeptidase complex iota chain | PROS-27 | PROS27 | PSA6_HUMAN | PSMA6 | Proteasome iota chain | p27K |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27399.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_106197 |
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| Residue: | 246 |
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| Sequence: | MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
ALAERD
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| BDBM50069989 |
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| n/a |
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| Name | BDBM50069989 |
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| Synonyms: | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-6-carboxamido)propanamido)butylboronic acid | BORTEZOMIB | CHEMBL325041 | Dipeptidyl boronic acid derivative | LDP-341 | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | PS-341 | Peptidyl boronic acid derivative | US11542283, Compound Velcade | Velcade | cid_387447 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25BN4O4 |
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| Mol. Mass. | 384.237 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |r| |
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| Structure | 
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