| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
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| Ligand | BDBM8921 |
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| Substrate/Competitor | BDBM8582 |
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| Meas. Tech. | CYP11B Assay |
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| pH | 7.4±n/a |
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| Temperature | 310.15±n/a K |
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| Comments | 9% inhibition of S. pombe expressing human CYP11B2 @ 500 nM inhibitor. |
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| Citation |  Voets, M; Antes, I; Scherer, C; Muller-Vieira, U; Biemel, K; Barassin, C; Marchais-Oberwinkler, S; Hartmann, RW Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis. J Med Chem48:6632-42 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Cytochrome P450 11B2, mitochondrial |
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| Name: | Cytochrome P450 11B2, mitochondrial |
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| Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
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| Type: | Protein |
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| Mol. Mass.: | 57582.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P19099 |
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| Residue: | 503 |
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| Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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| BDBM8921 |
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| BDBM8582 |
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| Name | BDBM8921 |
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| Synonyms: | 3-(2-methoxy-6-pyridin-3-yl-1-naphthyl)pyridine | 3-[6-methoxy-5-(pyridin-3-yl)naphthalen-2-yl]pyridine | Pyridine-substituted naphthalene 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16N2O |
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| Mol. Mass. | 312.3645 |
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| SMILES | COc1ccc2cc(ccc2c1-c1cccnc1)-c1cccnc1 |
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| Structure | 
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