| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 2 |
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| Ligand | BDBM330052 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | OCT2 Inhibition Assay |
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| IC50 | 476±n/a nM |
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| Citation |  Bacon, EM; Cai, ZR; Chen, X; Cottell, JJ; Desai, MC; Ji, M; Jin, H; Lazerwith, SE; Mish, MR; Morganelli, PA; Pyun, H; Taylor, JG; Trejo Martin, TA Substituted 1,4-methanopyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections US Patent US11548901 Publication Date 1/10/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 2 |
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| Name: | Solute carrier family 22 member 2 |
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| Synonyms: | OCT2 | Organic cation transporter 2 | S22A2_HUMAN | SLC22A2 | hOCT2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62591.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1484077 |
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| Residue: | 555 |
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| Sequence: | MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELS
LRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLG
PCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL
LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF
YQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAM
RIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV
LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA
SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII
TPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKE
KMIYLQVQKLDIPLN
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| BDBM330052 |
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| n/a |
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| Name | BDBM330052 |
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| Synonyms: | (1R,4S,12aS)-7-hydroxy-6,8-dioxo-N-(2,4,6-trifluorobenzyl)-1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1′,2′-d]pyrazine-9-carboxamide | US10689399, Compound 55 | US11548901, Compound 55 | US9663528, 55 | US9732092, Compound 55 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18F3N3O4 |
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| Mol. Mass. | 433.3805 |
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| SMILES | Oc1c2C(=O)N3[C@H]4CC[C@H](C4)[C@H]3Cn2cc(C(=O)NCc2c(F)cc(F)cc2F)c1=O |THB:12:11:7.8:10,3:5:7.8:10| |
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| Structure | 
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