| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Solute carrier family 22 member 2 |
|---|
| Ligand | BDBM330054 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | OCT2 Inhibition Assay |
|---|
| IC50 | 94.0±n/a nM |
|---|
| Citation |  Bacon, EM; Cai, ZR; Chen, X; Cottell, JJ; Desai, MC; Ji, M; Jin, H; Lazerwith, SE; Mish, MR; Morganelli, PA; Pyun, H; Taylor, JG; Trejo Martin, TA Substituted 1,4-methanopyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections US Patent US11548901 Publication Date 1/10/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Solute carrier family 22 member 2 |
|---|
| Name: | Solute carrier family 22 member 2 |
|---|
| Synonyms: | OCT2 | Organic cation transporter 2 | S22A2_HUMAN | SLC22A2 | hOCT2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 62591.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1484077 |
|---|
| Residue: | 555 |
|---|
| Sequence: | MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELS
LRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLG
PCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL
LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF
YQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAM
RIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV
LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA
SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII
TPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKE
KMIYLQVQKLDIPLN
|
|
|
|---|
| BDBM330054 |
|---|
| n/a |
|---|
| Name | BDBM330054 |
|---|
| Synonyms: | (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,5-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide | US10689399, Compound 64 | US11548901, Compound 64 | US9663528, 64 | US9732092, Compound 64 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18F3N3O5 |
|---|
| Mol. Mass. | 449.3799 |
|---|
| SMILES | Oc1c2C(=O)N3[C@H]4CC[C@H](C4)O[C@@H]3Cn2cc(C(=O)NCc2cc(F)c(F)cc2F)c1=O |THB:13:12:8.7:10,3:5:8.7:10| |
|---|
| Structure | 
|
|---|
Search and Browse
