Ki Summary

Reaction Details

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Target

Solute carrier family 22 member 2

Ligand

BDBM589186

Substrate/Competitor

n/a

Meas. Tech.

OCT2 Inhibition Assay

IC50

1357±n/a nM

Citation

Bacon, EM; Cai, ZR; Chen, X; Cottell, JJ; Desai, MC; Ji, M; Jin, H; Lazerwith, SE; Mish, MR; Morganelli, PA; Pyun, H; Taylor, JG; Trejo Martin, TA Substituted 1,4-methanopyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections US Patent US11548901 Publication Date 1/10/2023

More Info.:

Get all data from this article, Assay Method

Solute carrier family 22 member 2

Name:

Solute carrier family 22 member 2

Synonyms:

OCT2 | Organic cation transporter 2 | S22A2_HUMAN | SLC22A2 | hOCT2

Type:

PROTEIN

Mol. Mass.:

62591.01

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1484077

Residue:

555

Sequence:

MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELS
LRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLG
PCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL
LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF
YQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAM
RIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV
LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA
SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII
TPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKE
KMIYLQVQKLDIPLN

BDBM589186

n/a

Name

BDBM589186

Synonyms:

US11548901, Compound 96

Type

Small organic molecule

Emp. Form.

C20H16F3N3O4

Mol. Mass.

419.3539

SMILES

Oc1c2C(=O)N3C4CC(C4)C3Cn2cc(C(=O)NCc2c(F)cc(F)cc2F)c1=O |(7.23,3.85,;7.23,2.31,;5.89,1.54,;4.56,2.31,;4.56,3.85,;3.23,1.54,;1.76,2.02,;.86,.77,;1.76,-.48,;2.07,.77,;3.23,,;4.56,-.77,;5.89,,;7.23,-.77,;8.56,,;9.89,-.77,;11.23,,;9.89,-2.31,;11.23,-3.08,;11.23,-4.62,;9.89,-5.39,;8.56,-4.62,;9.89,-6.93,;11.23,-7.7,;11.23,-9.24,;12.56,-6.93,;12.56,-5.39,;13.9,-4.62,;8.56,1.54,;9.89,2.31,)|

Structure