| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 12 |
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| Ligand | BDBM589995 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DLK Kd Determinations |
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| Kd | 0.210±n/a nM |
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| Citation |  Soth, MJ; Le, K; Jones, P; Cross, J Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease US Patent US11560366 Publication Date 1/24/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 12 |
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| Name: | Mitogen-activated protein kinase kinase kinase 12 |
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| Synonyms: | DLK | Dual leucine zipper bearing kinase | Leucine-zipper protein kinase | M3K12_HUMAN | MAP3K12 | MAPK-upstream kinase | MUK | Mitogen-activated protein kinase kinase kinase 12 | Mixed lineage kinase | ZPK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93216.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1460553 |
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| Residue: | 859 |
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| Sequence: | MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTHVLQLHEQDAGGPGG
AAGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEV
PFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVC
TQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSP
NMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVL
WELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQI
LLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELR
HALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKPHPSRGL
LHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRS
RRGKTRHRKASAKGSCGDLPGLRTAVPPHEPGGPGSPGGLGGGPSAWEACPPALRGLHHD
LLLRKMSSSSPDLLSAALGSRGRGATGGAGDPGSPPPARGDTPPSEGSAPGSTSPDSPGG
AKGEPPPPVGPGEGVGLLGTGREGTSGRGGSRAGSQHLTPAALLYRAAVTRSQKRGISSE
EEEGEVDSEVELTSSQRWPQSLNMRQSLSTFSSENPSDGEEGTASEPSPSGTPEVGSTNT
DERPDERSDDMCSQGSEIPLDPPPSEVIPGPEPSSLPIPHQELLRERGPPNSEDSDCDST
ELDNSNSVDALRPPASLPP
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| BDBM589995 |
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| n/a |
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| Name | BDBM589995 |
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| Synonyms: | (R)-1-(4-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-1-(3-(4,4-difluoropiperidin-1-yl)bicyclo[1.1.1]pentan-1-yl)-1H-imidazol-2-yl)-2-methylpropan-1-ol | US11560366, Example 7a |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28F5N5O |
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| Mol. Mass. | 485.4933 |
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| SMILES | CC(C)[C@@H](O)c1nc(cn1C12CC(C1)(C2)N1CCC(F)(F)CC1)-c1cnc(N)c(c1)C(F)(F)F |r| |
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| Structure | 
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