| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 14 |
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| Ligand | BDBM590200 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Usp14 Inhibition Assay |
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| IC50 | <50±n/a nM |
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| Citation |  Cullen, M; Bastos, CM; Parks, D; Munoz, B Proteasome activity enhancing compounds US Patent US11560385 Publication Date 1/24/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Ubiquitin carboxyl-terminal hydrolase 14 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 14 |
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| Synonyms: | Deubiquitinating enzyme 14 | TGT | UBP14_HUMAN | USP14 | Ubiquitin thioesterase 14 | Ubiquitin-specific-processing protease 14 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56058.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103728 |
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| Residue: | 494 |
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| Sequence: | MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGN
IKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATV
QCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLH
MAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKK
SLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITK
QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCT
PELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDL
QAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLY
GPRRVEIMEEESEQ
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| BDBM590200 |
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| n/a |
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| Name | BDBM590200 |
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| Synonyms: | US11560385, Compound 10A | US11560385, Compound 15A |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26ClN3O2 |
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| Mol. Mass. | 447.957 |
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| SMILES | Cc1c(C(=O)CN2C3CCC2[C@@H](O)C3)c2ccc(CCC#N)cc2n1-c1ccc(Cl)cc1 |r,THB:5:6:11.13:9.8,12:11:9.8:6| |
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| Structure | 
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