| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA-directed RNA polymerase subunit beta' |
|---|
| Ligand | BDBM592159 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| IC50 | 8000±n/a nM |
|---|
| Citation |  Ebright, RH; Ebright, YW; Freundlich, JS; Gallardo-Macias, R; Li, S Antibacterial agents: arylalkylcarboxamido phloroglucinols US Patent US11572337 Publication Date 2/7/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA-directed RNA polymerase subunit beta' |
|---|
| Name: | DNA-directed RNA polymerase subunit beta' |
|---|
| Synonyms: | RNA polymerase subunit beta' | RNAP subunit beta' | RPOC_STAAU | Transcriptase subunit beta' | rpoC |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 118610.70 |
|---|
| Organism: | n/a |
|---|
| Description: | P0C1T4 |
|---|
| Residue: | 1057 |
|---|
| Sequence: | MIDVNNFHYMKIGLASPEKIRSWSFGEVKKPETINYRTLKPEKDGLFCERIFGPTKDWEC
SCGKYKRVRYKGMVCDRCGVEVTKSKVRRERMGHIELAAPVSHIWYFKGIPSRMGLLLDM
SPRALEEVIYFASYVVVDPGPTGLEKKTLLSEAEFRDYYDKYPGQFVAKMGAEGIKDLLE
EIDLDEELKLLRDELESATGQRLTRAIKRLEVVESFRNSGNKPSWMILDVLPIIPPEIRP
MAQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPGIIVQNEKRMLQEAVDALIDNGR
RGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIAVGPSLKMYQCGLPKE
MALELFKPFVMKELVQREIATNIKNAKSKIERMDDEVWDVLEEVIREHPVLLNRAPTLHR
LGIQAFEPTLVEGRAIRLHPLVTTAYNADFDGDQMAVHVPLSKEAQAEARMLMLAAQNIL
NPKDGKPVVTPSQDMVLGNYYLTLERKDAVNTGAIFNNTNEVLKAYANGFVHLHTRIGVH
ASSFNNPTFTEEQNKKILATSVGKIIFNEIIPDSFAYINEPTQENLERKTPNRNFIDPTT
LGEGGLKEYFENEELIEPFNKKFLGNIIAEVFNRFSITDTSMMLDRMKDLGFKFSSKAGI
TVGVADIVVLPDKQQILDEHEKLVDRITKQFNRGLITEEERYNAVVEIWTDAKDQIQGEL
MQSLDKTNPIFMMSDSGARGNASNFTQLAGMRGLMAAPSGKIIELPITSSFREGLTVLEY
FISTHGARKGLADTALKTADSGYLTRRLVDVAQDVIVREEDCGTDRGLLVSDIKEGTEMI
EPFIERIEGRYSKETIRHPETDEIIIRPDELITPEIAKKITDAGIEQMYIRSAFTCNARH
GVCEKCYGKNLATGEKVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVAGSDITQGLPRI
QEIFEARNPKGQAVITEIEGVVEDIKLAKDRQQEIVVKGANETRSYLASGTSRIIVEIGQ
PVQRGEVLTEGSIEPKNYLSVAGLNATESYLLKEVQK
|
|
|
|---|
| BDBM592159 |
|---|
| n/a |
|---|
| Name | BDBM592159 |
|---|
| Synonyms: | US11572337, Compound 0MTK232 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H17Cl2NO5 |
|---|
| Mol. Mass. | 434.269 |
|---|
| SMILES | Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(Cl)cc3)cc2)c(O)c1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
