| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor |
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| Ligand | BDBM307668 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of LPS-induced TNFalpha in Human PBMCs |
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| IC50 | 5500±n/a nM |
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| Citation |  Brown, SD ASK1 inhibitor compounds and uses thereof US Patent US10150755 Publication Date 12/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tumor necrosis factor |
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| Name: | Tumor necrosis factor |
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| Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
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| Type: | Enzyme |
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| Mol. Mass.: | 25645.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P01375 |
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| Residue: | 233 |
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| Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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| BDBM307668 |
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| n/a |
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| Name | BDBM307668 |
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| Synonyms: | 2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridin-2-yl)-6- (5- cyclopropylpyrazin- 2-yll)isoindolin-1- one | US10150755, Compound 60 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21N7O |
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| Mol. Mass. | 435.4805 |
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| SMILES | O=C1N(Cc2ccc(cc12)-c1cnc(cn1)C1CC1)c1cccc(n1)-c1nncn1C1CC1 |
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| Structure | 
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