Ki Summary

Reaction Details

Report a problem with these data

Target

D(3) dopamine receptor

Ligand

BDBM593799

Substrate/Competitor

n/a

Meas. Tech.

Binding Inhibition for Dopamine D3 Receptor

0.086±n/a nM

Citation

Tobinaga, H; Masuda, K Condensed ring compounds having dopamine D3 receptor antagonistic effect US Patent US11578084 Publication Date 2/14/2023

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

DRD3 | DRD3_HUMAN | Dopamine D3 receptor

Type:

PROTEIN

Mol. Mass.:

44213.40

Organism:

Homo sapiens

Description:

ChEMBL_105671

Residue:

400

Sequence:

MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM593799

n/a

Name

BDBM593799

Synonyms:

US11578084, Compound I-082

Type

Small organic molecule

Emp. Form.

C27H35F2N5O2S

Mol. Mass.

531.661

SMILES

Cc1ncc(\C=C\C(=O)N[C@H]2CC[C@H](CCN3CCc4nc(OC5CC(F)(F)C5)sc4CC3)CC2)cn1 |r,wU:13.13,wD:10.9,(14.04,4.8,;12.71,4.03,;12.71,2.49,;11.37,1.72,;10.04,2.49,;8.7,1.72,;7.37,2.49,;6.04,1.72,;6.04,.18,;4.7,2.49,;3.37,1.72,;2.04,2.49,;.7,1.72,;.7,.18,;-.63,-.59,;-1.97,.18,;-3.3,-.59,;-4.66,.14,;-6.07,-.46,;-6.48,-2.02,;-7.95,-2.49,;-7.95,-4.03,;-9.28,-4.8,;-10.61,-4.03,;-11.01,-2.55,;-12.5,-2.94,;-14.04,-2.94,;-13.27,-1.61,;-12.1,-4.43,;-6.48,-4.51,;-5.58,-3.26,;-4.04,-3.26,;-3.02,-2.1,;2.04,-.59,;3.37,.18,;10.04,4.03,;11.37,4.8,)|

Structure