Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM593888

Substrate/Competitor

n/a

Meas. Tech.

Binding Inhibition for Dopamine D3 Receptor

0.071±n/a nM

Citation

Tobinaga, H; Masuda, K Condensed ring compounds having dopamine D3 receptor antagonistic effect US Patent US11578084 Publication Date 2/14/2023

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

DRD3 | DRD3_HUMAN | Dopamine D3 receptor

Type:

PROTEIN

Mol. Mass.:

44213.40

Organism:

Homo sapiens

Description:

ChEMBL_105671

Residue:

400

Sequence:

MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM593888

n/a

Name

BDBM593888

Synonyms:

US11578084, Compound I'-36

Type

Small organic molecule

Emp. Form.

C22H31F3N6O2S

Mol. Mass.

500.581

SMILES

Cn1ncc(CC(=O)N[C@H]2CC[C@H](CCN3CCc4nc(OCC(F)(F)F)sc4CC3)CC2)n1 |r,wU:12.12,wD:9.8,(13.14,2.77,;11.6,2.77,;10.79,1.46,;9.29,1.83,;9.18,3.36,;7.84,4.13,;6.51,3.36,;6.51,1.82,;5.17,4.13,;3.84,3.36,;2.51,4.13,;1.17,3.36,;1.17,1.82,;-.16,1.05,;-1.49,1.82,;-2.83,1.05,;-4.1,1.92,;-5.57,1.46,;-6.13,.03,;-7.64,-.29,;-7.8,-1.82,;-9.14,-2.59,;-10.47,-1.82,;-11.8,-2.59,;-13.14,-3.36,;-11.8,-4.13,;-13.14,-1.82,;-6.4,-2.45,;-5.36,-1.3,;-3.84,-1.53,;-2.71,-.48,;2.51,1.05,;3.84,1.82,;10.6,3.95,)|

Structure