| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol kinase alpha |
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| Ligand | BDBM594321 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro DGK Inhibition Assay |
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| IC50 | 2.00±n/a nM |
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| Citation |  Velaparthi, U; Olson, RE; Darne, CP; Dasgupta, B; Warrier, JS; Rahaman, H; Jalagam, PR; Roy, S; Grunenfelder, DC Substituted pyridopyrimidinonyl compounds useful as T cell activators US Patent US11584747 Publication Date 2/21/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol kinase alpha |
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| Name: | Diacylglycerol kinase alpha |
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| Synonyms: | 2.7.1.107 | 80 kDa diacylglycerol kinase | DAG kinase alpha | DAGK | DAGK1 | DGK-alpha | DGKA | DGKA_HUMAN | Diacylglycerol kinase alpha | Diglyceride kinase alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82631.86 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117392 |
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| Residue: | 735 |
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| Sequence: | MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIY
LEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFK
LYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEW
VRAGATTVPLLVLLGLEMTLKDDGQHMWRPKRFPRPVYCNLCESSIGLGKQGLSCNLCKY
TVHDQCAMKALPCEVSTYAKSRKDIGVQSHVWVRGGCESGRCDRCQKKIRIYHSLTGLHC
VWCHLEIHDDCLQAVGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNL
STSEALRIDPVPNTHPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRL
FKDVPDSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ
NLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPVPFQIINNYFSIGVDASIAHRFHIM
REKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVL
NIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLE
GAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWMQTPCTIKITHKNQMPML
MGPPPRSTNFFGFLS
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| BDBM594321 |
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| n/a |
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| Name | BDBM594321 |
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| Synonyms: | US11584747, Example 116 | US11584747, Example 117 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27F3N6O |
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| Mol. Mass. | 484.5167 |
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| SMILES | CC[C@H]1CN(C(C)c2ccc(cc2)C(F)(F)F)[C@H](C)CN1c1nc(=O)n(C)c2ccc(nc12)C#N |r| |
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| Structure | 
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