Reaction Details |
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Target | Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Ligand | BDBM597684 |
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Substrate/Competitor | n/a |
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Meas. Tech. | SPR Assay to Determine Binding Affinity to FKBP12 |
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Kd | <0.3±n/a nM |
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Citation | Kincaid, J MTORC1 modulators and uses thereof US Patent US11603377 Publication Date 3/14/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Name: | Peptidyl-prolyl cis-trans isomerase FKBP1A |
Synonyms: | 12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B |
Type: | Isomerase |
Mol. Mass.: | 11953.09 |
Organism: | Homo sapiens (Human) |
Description: | P62942 |
Residue: | 108 |
Sequence: | MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
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BDBM597684 |
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n/a |
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Name | BDBM597684 |
Synonyms: | US11603377, Compound 5 |
Type | Small organic molecule |
Emp. Form. | C53H84N2O15S |
Mol. Mass. | 1021.303 |
SMILES | CO[C@@H]1C[C@H](C[C@@H](C)C2CC(=O)C(C)\C=C(C)\C(O)C(OC)C(=O)C(C)CC\C=C\C=C\C=C(C)\[C@@H](C[C@H]3CC[C@H](C)[C@](O)(O3)C(=O)C(=O)N(C)C(C)C(=O)O2)NS(=O)(=O)CC2CCOCC2)CC[C@H]1O |r,c:14,32,t:28,30| |
Structure |
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