| Reaction Details |
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 | Report a problem with these data |
| Target | Peptidyl-prolyl cis-trans isomerase FKBP1A |
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| Ligand | BDBM597687 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SPR Assay to Determine Binding Affinity to FKBP12 |
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| Kd | <0.3±n/a nM |
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| Citation |  Kincaid, J MTORC1 modulators and uses thereof US Patent US11603377 Publication Date 3/14/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Peptidyl-prolyl cis-trans isomerase FKBP1A |
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| Name: | Peptidyl-prolyl cis-trans isomerase FKBP1A |
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| Synonyms: | 12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B |
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| Type: | Isomerase |
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| Mol. Mass.: | 11953.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P62942 |
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| Residue: | 108 |
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| Sequence: | MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
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| BDBM597687 |
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| n/a |
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| Name | BDBM597687 |
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| Synonyms: | US11603377, Compound 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C54H88N2O17S |
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| Mol. Mass. | 1069.345 |
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| SMILES | COCCOCCS(=O)(=O)N[C@@H]1C[C@H]2CC[C@H](C)[C@](O)(O2)C(=O)C(=O)N(C)C(C)C(=O)OC(CC(=O)C(C)\C=C(C)\C(O)C(OC)C(=O)C(C)CC\C=C\C=C\C=C1/C)[C@H](C)C[C@@H]1CC[C@@H](OCCO)[C@@H](C1)OC |r,c:39,t:53,55,57| |
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| Structure | 
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