| Reaction Details |
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 | Report a problem with these data |
| Target | Peptidyl-prolyl cis-trans isomerase FKBP5 |
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| Ligand | BDBM597700 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SPR Assay to Determine Binding Affinity to FKBP51 |
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| Kd | 55±n/a nM |
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| Citation |  Kincaid, J MTORC1 modulators and uses thereof US Patent US11603377 Publication Date 3/14/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Peptidyl-prolyl cis-trans isomerase FKBP5 |
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| Name: | Peptidyl-prolyl cis-trans isomerase FKBP5 |
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| Synonyms: | 51 kDa FK506-binding protein | 51 kDa FKBP | 54 kDa progesterone receptor-associated immunophilin | AIG6 | Androgen-regulated protein 6 | FF1 antigen | FK506-binding protein 5 | FKBP-5 | FKBP-51 | FKBP5 | FKBP51 | FKBP54 | FKBP5_HUMAN | HSP90-binding immunophilin | PPIase FKBP5 | Rotamase | p54 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51207.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_952910 |
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| Residue: | 457 |
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| Sequence: | MTTDEGAKNNEESPTATVAEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGK
LSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLP
KIPSNATLFFEIELLDFKGEDLFEDGGIIRRTKRKGEGYSNPNEGATVEIHLEGRCGGRM
FDCRDVAFTVGEGEDHDIPIGIDKALEKMQREEQCILYLGPRYGFGEAGKPKFGIEPNAE
LIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEM
EYGLSEKESKASESFLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEA
QLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRRIYANMFKKFAEQD
AKEEANKAMGKKTSEGVTNEKGTDSQAMEEEKPEGHV
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| BDBM597700 |
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| n/a |
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| Name | BDBM597700 |
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| Synonyms: | US11603377, Compound 21 |
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| Type | Small organic molecule |
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| Emp. Form. | C52H82N2O14S |
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| Mol. Mass. | 991.277 |
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| SMILES | CO[C@@H]1C[C@H](C[C@@H](C)C2CC(=O)C(C)\C=C(C)\C(O)C(OC)C(=O)C(C)CC\C=C\C=C\C=C(C)\C(C[C@H]3CC[C@H](C)[C@](O)(O3)C(=O)C(=O)N(C)C(C)C(=O)O2)NS(C)(=O)=O)CC[C@H]1OC1CCC1 |r,c:14,32,t:28,30| |
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| Structure | 
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