Reaction Details |
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Target | Mitogen-activated protein kinase kinase kinase kinase 1 |
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Ligand | BDBM598285 |
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Substrate/Competitor | n/a |
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Meas. Tech. | TBD |
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Ki | <0.013±n/a nM |
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Citation | Liang, J; Mendonca, RV; Siu, M; Tellis, J; Wang, W; Wei, B; Chan, B; Choo, EF; Drobnick, J; Gazzard, LJ; Heffron, T 8-aminoisoquinoline compounds and uses thereof US Patent US11612606 Publication Date 3/28/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase kinase kinase kinase 1 |
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Name: | Mitogen-activated protein kinase kinase kinase kinase 1 |
Synonyms: | HPK1 | M4K1_HUMAN | MAP4K1 |
Type: | PROTEIN |
Mol. Mass.: | 91316.07 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_586597 |
Residue: | 833 |
Sequence: | MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
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BDBM598285 |
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n/a |
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Name | BDBM598285 |
Synonyms: | 1-(2-Acetyl-2-azaspiro[3.3]heptan-6-yl)- 3-(8-amino-7-fluoro-6-(8-methyl-2,3- dihydro-1H-pyrido[2,3-b][1,4]oxazin-7- yl)isoquinolin-3-yl)urea | US11612606, Compound 709 |
Type | Small organic molecule |
Emp. Form. | C26H28FN7O3 |
Mol. Mass. | 505.544 |
SMILES | CC(=O)N1CC2(CC(C2)NC(=O)Nc2cc3cc(c(F)c(N)c3cn2)-c2cnc3OCCNc3c2C)C1 |
Structure |
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