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TargetMitogen-activated protein kinase kinase kinase kinase 1
LigandBDBM598291
Substrate/Competitorn/a
Meas. Tech.TBD
Ki<0.013±n/a nM
Citation Liang, JMendonca, RVSiu, MTellis, JWang, WWei, BChan, BChoo, EFDrobnick, JGazzard, LJHeffron, T 8-aminoisoquinoline compounds and uses thereof US Patent US11612606 Publication Date 3/28/2023
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase kinase kinase kinase 1
Name:Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:HPK1 | M4K1_HUMAN | MAP4K1
Type:PROTEIN
Mol. Mass.:91316.07
Organism:Homo sapiens (Human)
Description:ChEMBL_586597
Residue:833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCRE
VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMA
PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK
GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI
GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP
PRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQL
SPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMK
RKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPS
RTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTK
IQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVF
ALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDM
VMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQ
LLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
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  Blast E-value cutoff:
BDBM598291
n/a
NameBDBM598291
Synonyms:1-(8-Amino-7-fluoro-6-(8-methyl-2,3- dihydro-1H-pyrido[2,3-b][1,4]oxazin-7- yl)isoquinolin-3-yl)-3-(3,3- difluorocyclobutyl)urea | US11612606, Compound 714
TypeSmall organic molecule
Emp. Form.C22H21F3N6O2
Mol. Mass.458.4363
SMILESCc1c2NCCOc2ncc1-c1cc2cc(NC(=O)NC3CC(F)(F)C3)ncc2c(N)c1F
Structure
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