| Reaction Details |
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 | Report a problem with these data |
| Target | Rho-associated protein kinase 1 [1-535] |
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| Ligand | BDBM598522 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Determination of Compound's ROCK Inhibitory Activity In Vitro (Z'Lyte Assay) |
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| IC50 | 65.0±n/a nM |
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| Citation |  Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R Inhibitors of RHO associated coiled-coil containing protein kinase US Patent US11613531 Publication Date 3/28/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Rho-associated protein kinase 1 [1-535] |
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| Name: | Rho-associated protein kinase 1 [1-535] |
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| Synonyms: | ROCK1 | ROCK1_HUMAN | Rho-associated protein kinase 1 (ROCK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 62220.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 1-535 |
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| Residue: | 535 |
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| Sequence: | MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA
DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
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| BDBM598522 |
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| n/a |
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| Name | BDBM598522 |
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| Synonyms: | N-(2-(1,4-diazepan-1-yl)-5-methoxypyrimidin-4-yl)-1H-indazol-5-amine | US11613531, Example 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H21N7O |
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| Mol. Mass. | 339.3949 |
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| SMILES | COc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1CCCNCC1 |
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| Structure | 
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