| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Rho-associated protein kinase 1 [1-535] |
|---|
| Ligand | BDBM598552 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Determination of Compound's ROCK Inhibitory Activity In Vitro (Z'Lyte Assay) |
|---|
| IC50 | 20.0±n/a nM |
|---|
| Citation |  Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R Inhibitors of RHO associated coiled-coil containing protein kinase US Patent US11613531 Publication Date 3/28/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Rho-associated protein kinase 1 [1-535] |
|---|
| Name: | Rho-associated protein kinase 1 [1-535] |
|---|
| Synonyms: | ROCK1 | ROCK1_HUMAN | Rho-associated protein kinase 1 (ROCK1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 62220.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | aa 1-535 |
|---|
| Residue: | 535 |
|---|
| Sequence: | MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA
DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
|
|
|
|---|
| BDBM598552 |
|---|
| n/a |
|---|
| Name | BDBM598552 |
|---|
| Synonyms: | N-(6-methyl-2-(3-methylpiperazin-1-yl)pyrimidin-4-yl)-1H-indazol-5-amine | US11613531, Example 204 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H21N7 |
|---|
| Mol. Mass. | 323.3955 |
|---|
| SMILES | CC1CN(CCN1)c1nc(C)cc(Nc2ccc3[nH]ncc3c2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
